Free Coupon Code Foundations of Genetics: Principles and Modern Applications 100% OFF

Udemy coupon code for Foundations of Genetics: Principles and Modern Applications course taught by Mohamed AL ashram, which has 8,842 students and is rated 4.2 out of 42 votes. This course is about 3 hour(s) in English and was updated on November 18, 2024. You can use this Udemy course with a free certificate and find the coupon at the bottom of this page.

understand genetics

the science of heredity. Genetics is concerned primarily with understanding

biological properties that are transmitted from parent tooffspring. The subject matter of genetics includes hered-

ity, the molecular nature of the genetic material, the waysin which genes (which determine the characteristics of

organisms) control life functions, and the distributionand behavior of genes in populations.Genetics is central to biology because gene activityunderlies all life processes, from cell structure and function to reproduction.

Learning what genes are, how genes are transmitted from generation to generation

he principles of heredity were not understood untilthe mid-nineteenth century, when Gregor Mendel ana-

lyzed quantitatively the results of crossing pea plants thatvaried in easily observable characteristics. He published

his results, but their significance was not realized in hislifetime. Several years after his death, however, re-

searchers realized that Mendel had discovered fundamental principles of heredity

The structure of DNA was first described in 1953, andsince that time genetics has become one of the most excit-

ing and ground-breaking sciences. Our understanding ofgene structure and function has progressed rapidly since

molecular techniques were developed to clone or amplifygenes, and rapid methods for sequencing DNA became

available.

Research in genetics underwent a revolution in 1972,when Paul Berg constructed the first recombinant DNA

molecule in vitro, and in 1973, when Herbert Boyer andStanley Cohen cloned a recombinant DNA molecule for

the first time. The development by Kary Mullis in 1986of the polymerase chain reaction (PCR) to amplify

specific segments of DNA spawned another revolution.Recombinant DNA technology, PCR, and other molecular

technologies are leading to an ever-increasing number ofexciting discoveries that are furthering our knowledge of

basic biological functions and will lead to improvementsin the quality of human life.

In recent years, the sequencing of the genomes ofa large number of viruses and organisms has changed thescope of experiments performed by geneticists. For example, we can study a genome’s worth of genes now in oneexperiment, allowing us to obtain a more complete understanding of gene expression.

understanding of the abstract nature of genes (fromthe transmission genetics part) with the molecular nature

of genes (from the molecular genetics is one of the best approach

Classic Principles.

classic experiments, a number of which have led to discoveries

These experiments include:

•Griffith’s transformation experiment

•Avery and his colleagues’ transformation experiment

•Hershey and Chase’s bacteriophage experiment

•Meselson and Stahl’s DNA replication experiment

•Beadle and Tatum’s one-gene–one-enzyme hypothe-

sis experiments

•Mendel’s experiments on gene segregation

•Thomas Hunt Morgan’s experiments on gene linkage

•Seymour Benzer’s experiments on the fine structure

of the gene

•Jacob and Monod’s experiments on the lac operon

The Subdisciplines of Genetics

Geneticists often divide genetics into four major subdis-

ciplines:

1. Transmission genetics (sometimes called classical

genetics) is the subdiscipline dealing with how genes

and genetic traits are transmitted from generation to

generation and how genes recombine (exchange be-

tween chromosomes). Analyzing the pattern of trait

transmission in a human pedigree or in crosses of ex-

perimental organisms is an example of a transmis-

sion genetics study.

2. Molecular genetics is the subdiscipline dealing with

the molecular structure and function of genes. Ana-

lyzing the molecular events involved in the gene

control of cell division, or the regulation of expres-

sion of all the genes in a genome, are examples of

molecular genetics studies. Genomic analysis is part

of molecular genetics.

3. Population genetics is the subdiscipline that studies

heredity in groups of individuals for traits that are de-

termined by one or only a few genes. Analyzing the

frequency of a disease-causing gene in the human pop-

ulation is an example of a population genetics study.

4. Quantitative genetics also considers the heredity of

traits in groups of individuals, but the traits of concern

are determined by many genes simultaneously. Analyz-

ing the fruit weight and crop yield in agricultural

plants are examples of quantitative genetics studies.

Weekly Modules Outline:

Week 1: Introduction to Genetics and Heredity

• Description: This week introduces the history of genetics, basic terminology, and the fundamental principles of heredity.

• Topics:

  • History of genetics: From Mendel to modern science

  • Basic genetic terminology: Genes, alleles, chromosomes, and genomes

  • Mendelian inheritance: Laws of segregation and independent assortment

  • Extensions to Mendelian genetics: Co-dominance and incomplete dominance

• Learning Objectives:

  • Understand basic genetic terms and concepts.

  • Apply Mendel’s principles to inheritance patterns.

Week 2: The Molecular Basis of Genetics

• Description: Explore the structure and function of DNA and RNA, and understand the processes of replication, transcription, and translation.

• Topics:

  • DNA structure and discovery

  • Central Dogma: From DNA to proteins

  • DNA replication mechanisms

  • RNA synthesis and types (mRNA, tRNA, rRNA)

  • Protein synthesis (translation)

• Learning Objectives:

  • Explain how genetic information is encoded and expressed.

  • Analyze the role of DNA and RNA in cellular functions.

Week 3: Chromosomal Basis of Inheritance

• Description: Delve into chromosomes, karyotypes, and how chromosomal behavior during meiosis impacts inheritance.

• Topics:

  • Chromosomal structure and organization

  • Sex determination and sex-linked traits

  • Meiosis and its genetic significance

  • Chromosomal abnormalities: Aneuploidy, deletions, and duplications

• Learning Objectives:

  • Correlate chromosomal behavior with genetic inheritance.

  • Identify the causes and effects of chromosomal abnormalities.

Week 4: Genetic Variation and Mutation

• Description: Study the sources of genetic variation, including mutations and their effects on gene expression and inheritance.

• Topics:

  • Types of mutations: Point mutations, insertions, deletions

  • Causes of mutations: Spontaneous and induced

  • Genetic recombination and its significance

  • Role of genetic variation in evolution

• Learning Objectives:

  • Recognize different types of mutations and their impact.

  • Explain the importance of genetic variation in natural selection.

Week 5: Population Genetics and Evolutionary Principles

• Description: Understand the genetic structure of populations and the factors influencing genetic diversity.

• Topics:

  • Hardy-Weinberg equilibrium: Assumptions and calculations

  • Forces of evolution: Mutation, selection, genetic drift, gene flow

  • Genetic basis of speciation

  • Applications of population genetics in conservation biology

• Learning Objectives:

  • Calculate allele frequencies and predict population trends.

  • Discuss the role of genetics in evolution and species adaptation.

Week 6: Biotechnology and Genetic Engineering

• Description: Explore the tools and techniques used to manipulate genetic material for research and applications.

• Topics:

  • Recombinant DNA technology

  • CRISPR-Cas9 and gene editing

  • Applications in medicine (gene therapy, personalized medicine)

  • Applications in agriculture (GMOs, pest-resistant crops)

• Learning Objectives:

  • Understand modern genetic tools and their applications.

  • Evaluate the ethical considerations of genetic engineering.

Week 7: Genetics in Medicine and Health

• Description: Examine the role of genetics in diagnosing, treating, and preventing diseases.

• Topics:

  • Genetic basis of inherited diseases

  • Pharmacogenomics: Personalized medicine

  • Cancer genetics: Oncogenes and tumor suppressors

  • Ethical and societal issues in medical genetics

• Learning Objectives:

  • Discuss the impact of genetics on healthcare.

  • Identify genetic factors underlying common diseases.

Week 8: Emerging Trends and Future Applications in Genetics

• Description: Conclude with a look at the future of genetics in science and society, including ethical considerations.

• Topics:

  • Advances in genomics: Human Genome Project and beyond

  • Epigenetics: Gene expression regulation

  • Synthetic biology and bioinformatics

  • Ethical, legal, and social implications of genetics research

• Learning Objectives:

  • Anticipate future challenges and opportunities in genetics.

  • Critically analyze the societal impact of genetic advances.